Carlos Tevez is in from the start, while Ryan Giggs and Paul Scholes are also among the subs.
Lucas starts in the midfield alongside Javier Mascherano, due to an injury on Xabi Alonso.
Manchester United team: Van der Sar, O’Shea, Ferdinand, Vidic, Evra, Ronaldo, Carrick, Anderson, Park, Rooney, Tevez. Subs: Foster, Berbatov, Giggs, Nani, Scholes, Evans, Fletcher.
Liverpool team: Reina, Arbeloa, Carragher, Skrtel, Aurelio, Mascherano, Lucas, Kuyt, Gerrard, Riera, Torres. Subs: Cavalieri, Dossena, Hyypia, Babel, Insua, Ngog, El Zhar.