Rooney picked up a minor knock while away on international duty for England.
The England striker should be fit for United’s midweek Champions League game at CSKA Moscow.
“Calf injuries can be troublesome,” said United boss Sir Alex Ferguson.
“We are trying our best to get him fit for Wednesday but I have my doubts on that. But Wayne should be fit for the Liverpool game.
“We know how difficult these things can be so we will not be taking any chances with the Moscow trip.”