Rooney has impressed for United recently, scoring his 21st goals of the season in their win over Manchester City in the Carling Cup semi-final on Wednesday.
Campbell is expected to start against United due to the injury suffered by Thomas Vermaelen.
Campbell said in The Sun: “He’s the talisman for United. He’s always going to pop up, he’s always dangerous.
“As a top striker, you have to watch him. In a flash, something can happen and they’re in.
“It’s a challenge. That’s what it’s all about. We’re at the business end of the season. It’s a big two weeks for the club. We have to get some points and go from there.”
Campbell added: “It’s massive, a great game to be involved in. I don’t think it’s going to determine the season but it’s going some part towards it.
“United have been there before. They’re a top side, they’ve top players. But so have we.
“I don’t know if I will be needed on Sunday but I’ve been training for a long time. So if it comes to it, I’ll have to be ready.”
