Ferdinand is struggling with a twinge in his back while Giggs is still out with a fracture in his arm.
Anderson will miss the rest of the season with a knee injury while Nani is still suspended.
Man Utd (from): Van der Sar, Kuszczak, Foster, Rafael, Neville, Brown, Evans, Vidic, De Laet, Evra, Fabio, Valencia, Obertan, Fletcher, Carrick, Scholes, Gibson, Park, Berbatov, Owen, Rooney, Diouf.