Manchester United will face French champions Marseille while Chelsea will face Danish side FC Copenhagen.
Champions League last 16 draw:
Roma v Shakhtar Donetsk
AC Milan v Tottenham
Valencia v Schalke
Inter Milan v Bayern Munich
Lyon v Real Madrid
Arsenal v Barcelona
Marseille v Manchester United
Copenhagen v Chelsea
First legs to be played on 15/16 and 22/23 February
Second legs to be played on 8/9 and 15/16 March