Enrique has been linked with the likes of Liverpool, Manchester United and French side Lyon.
The Spaniard has just one year left on his contract and the Magpies could decide to sell rather than allow the defender to leave for free at the end of next season.
The Newcastle manager said: “The Enrique situation is something we talked about. How possible is it going to be to get him over the line? There’s one or two here who possibly could go.
“It’s difficult because we’re finding it difficult to get him to come to the table. We’re safe, which was what his people said that they would wait for.
“It’s now the last game, and once we get the last game out of the way we’ll sit down and see where we are with it.
“We’re very hopeful he stays but there’s no point keeping a player who has set his sights on a club he has perceived is bigger. You can’t keep a player that’s unmotivated.”
