Hughes has signed a two-and-a-half year contract with QPR.
Hughes told the club’s official website: “It’s a great feeling to be back in football and to be the Manager of QPR.
“I’m fully aware of the challenge in the short and long term and I am genuinely excited about the ambition of the owners.
“Nobody can doubt the history of this great Football Club and the passion of its fantastically loyal supporters.
“Now the immediate priority is to consolidate our place in the Barclays Premier League, but beyond that, the future is very bright and fills me with great enthusiasm.”
QPR Chairman, Tony Fernandes, said: “Mark has a proven track record in the Premier League, bringing a wealth of experience at both Club and international level.
“He has a great passion to achieve as a Manager and has already been hugely successful in his career.
“His ambitions match those of the Board and we are delighted to have him at the helm.”
QPR Vice Chairman, Amit Bhatia, added: “Mark has a great managerial pedigree and has proven over the years to be a very astute Manager.
“I am looking forward to working with him to bring success to the Club.”