Szczesny made his Premier League debut in the 1-0 defeat at United on Monday and the youngster will retain his place for the clash with Stoke.
“I can see the comparisons, there is something presence-wise,” Wenger said.
“Confidence is vital in our job because you have to be convinced that you are made to turn up in front of 60,000 people and perform, and Wojciech has that.
“It is not easy to start you career at Manchester United, in such a big game, without being shaky. I believe he has the presence and personality.”