Kolo Toure is suspended, and the chance of William Gallas returning to first-team action are slim.
Arsenal youngster Johan Djourou could also miss Sunday’s clash, after struggling with a hamstring injury in the match against Porto last night.
Arsenal boss Arsene Wenger said: “We can focus on the game on Sunday now, but the Gallas is 80 per cent unlikely to play.
“Djourou is also a problem because he has a hamstring strain.”
Thierry Henry, Tomas Rosicky, Lauren and Abou Diaby will also miss the trip to Stamford Bridge.