The Dutch winger could be out for a further month with the groin injury that has kept him out of action since the 5-0 victory over Hamburg.
“It makes no sense that he could play [against Villarreal] because he hasn’t even returned to training yet. There are no reliable predictions of when he may return,” Bayern Munich club doctor Hans-Wilhelm Muller-Wohlfahrt told Kicker.
Bayern chief executive Karl-Heinz Rummenigge added: “I do not know if it will be two, three or four weeks.”