Beckham will face United in the Champions League with AC Milan, who he is on loan at for the rest of the season.
The England international made over 300 appearances for United before joining Real Madrid in 2003.
“When I knew the draw, I nearly cried,” revealed Beckham.
“I love the club. It’s going to be an emotional night.
“I have never returned to Old Trafford in six years. It has always been a special place in my heart.”