The shock to Brazil was labelled “Macabre Thursday” by award-winning writer and soccer pundit Luis Fernando Verissimo.
Internacional lost to Uruguayan giants Penarol, with Gremio falling to Universidad Catolica.
Brazilian champions Fluminense lost to Libertad of Paraguay despite having a 3-1 lead from the first leg, and Cruzeiro were stunned 2-0 at home by Once Caldas, meaning that three of the teams going out from Brazil suffered worse second leg results than first.