Mancienne is currently on loan at Championship leaders Wolves.
Tottenham striker Darren Bent has also been named in the 23-man squad, while Manchester United pair Wayne Rooney and Rio Ferdinand will miss the match with injuries.
LA Galaxy midfielder David Beckham was also missing from Fabio Capello’s squad.
“Our opponents Germany are always a very strong team, and when they play at home even more,” Capello said.
“Everyone has told me that it is not a friendly game against Germany, but I think this will be a friendly game. We will do some experiments and after this game I will know better some different players.”
England squad:
Carson, Hart, James, Bridge, Davies, Johnson, Terry, Lescott, Mancienne, Richards, Upson, Barry, Carrick, Downing, Lampard, Gerrard, Wright-Phillips, A Young, Agbonlahor, Bent, Crouch, Defoe, Walcott.