City cited his failure to achieve all of the club’s key objectives, bar Champions League qualification, as the reason for his departure.
In a statement the club said: “It is with regret that Manchester City football club announces that Roberto Mancini has been relieved of his duties as Manchester City manager.
“This has been a difficult decision for the owner, chairman and board to make and it is the outcome of a planned end-of-season review process that has been brought forward in light of recent speculation and out of respect for Roberto and his extensive contributions to the football club.
“Despite everyone’s best efforts, the club has failed to achieve any of its stated targets this year, with the exception of qualification for next season’s Uefa Champions League.
“This, combined with an identified need to develop a holistic approach to all aspects of football at the club, has meant that the decision has been taken to find a new manager for the 2013-14 season and beyond.”