The 25-year-old has recently been linked with the likes of Atletico Madrid, Tottenham, Fulham and Juventus.
“If the player (Osvaldo) wants to go there is a buy-out clause of 30million euros and the league starts in two weeks,” Pochettino said in Sport.
“The time has come to put the cards on the table. As far as I am concerned he is a player that is difficult to replace if he goes.
“It isn’t good to not have things clear at this stage.”