The Udinese coach takes his side to Liverpool hopeful of improving on their opening day draw with Anzhi Makhachkala.
“The atmosphere will certainly be impressive and the lads might not be accustomed to that kind of pressure-cooker atmosphere,” said Guidolin.
“Still, I think our focus ought to be on Liverpool, who are a great team. After all, atmosphere is all well and good, but the games are played on the pitch.
“Getting a result here would certainly be extraordinary and important for our confidence.”