Jol has signed a two-year contract and replaces Mark Hughes, who resigned as Fulham boss last Thursday.
“I am very happy to join Fulham Football Club, a wonderful traditional club,” he told his new club’s official website.
“It is a club with good, solid foundations and a great fan base.
“I am looking forward to being part of the Fulham family and thank the chairman for the trust he’s shown in me.”
Fulham have the option to extend Jol’s contract into a third year.