The Biancocelesti are 14 points clear of rivals Roma on the Serie A table.
“I don’t think my team goes into the derby as favourites,” said President Lotito. “We must remain humble, determined and concentrated.
“It will be above all a spectacular game for all of our fans. I don’t think Roma are in crisis. Football is made of moments that so far have been unlucky for them.
“I just hope the derby will be a match of qualify and that the best team wins.”