Berbatov got a minor injury in the 1-0 victory over Sunderland on Saturday while Carrick is struggling with a thigh problem.
“Berbatov is injured but we’re hopeful,” Ferguson told the Evening Standard.
“He got a kick in the Achilles on Saturday and we need to get rid of the swelling first and then see.
“Carrick has a thigh injury and we hope he will be all right.
“Tottenham is an important game but Rooney is suspended and Patrice Evra too. So we’ve got to utilise our pool and pick the right team on Saturday.”