Valencia will miss the games against Mexico on May 28 and Canada on June 1, because he will be involved in the Champions League final for United against Barcelona.
But the winger may play a part in the clash with Greece six days later in the US.
Full Ecuador squad:
Goalkeeper: Marcelo Elizaga (Deportivo Quito), Maximo Banguera (Barcelona), Alexander Dominguez (Liga de Quito).
Defenders: Juan Carlos Paredes (Deportivo Quito), Neicer Reascos (Liga de Quito), Giovanni Caicedo (Liga de Quito), Diego Calderon (Liga de Quito), Jorge Guagua (Liga de Quito), Luis Checa (Deportivo Quito), Frickson Erazo (El Nacional), Walter Ayovi (Monterrey).
Midfielder: Segundo Castillo (Deportivo Quito), Oswaldo Tilson Minda (Deportivo Quito), Luis Fernando Saritama (Deportivo Quito), Michael Arroyo (San Luis), Flavio Caicedo (El Nacional), Edison Mendez (Emelec), Cristian Noboa ( Rubin Kazan), Antonio Valencia (Manchester United).
Attackers: Jaime Ayovi (Toluca), Christian Benitez (Santos), Felipe Caicedo (Levante), Joao Plata ( Toronto).