The United trio have not travelled with the rest of the team to Scotland.
Van der Sar has been rested and England goalkeeper Ben Foster is expected to be given the nod to make his debut in the Champions League for United.
Brown is struggling with an ankle injury, but is expected to be ready for the clash with Arsenal on Saturday.
It is expected that Brazilian whizkid Rafael da Silva will star at right-back for United, with Gary Neville being left in Manchester.
