A brace from Mexican striker Javier Hernandez settled the tie at Old Trafford in a relatively comfortable victory over the French side.
Hernandez gave United the lead after only 5 minutes with a close range finish from Rooney’s low cross.
After surviving a Brown mis-kick in the box and an effort from Cheyrou, the Mexican poacher latched onto Giggs’ cross to double United’s lead.
Marseille found hope in a late comeback after Brown nodded a Gonzalez corner past Van Der Sar, but were unable to apply any serious pressure and United held on for the win.