Milito had only just returned from injury for Inter Milan against CFR Cluj last night, but he was carried off after only six minutes.
“It’s his cruciate ligament, a new type of injury for Diego, nothing to do with the problems he’s had before,” coach Andrea Stramaccioni told reporters.
“We’re gutted for Diego as a person first and foremost, and then of course for what he represents as a player. We need to see when he’ll have the operation.”