Ferguson is expected to give several youngsters a chance to impress on Wednesday.
“There will be complete change. Just the same as we had at Leeds and Aldershot,” Sir Alex told the club’s official website.
Both Federcio Macheda and Mame Biram Diouf are likely to start against Crystal Palace.
“Ravel Morrison was in the squad for Wednesday’s game [against Benfica]. He’s a very, very talented boy, of course, and he’ll possibly be on the bench, at least, in midweek,” continued Ferguson.
“But I’ve got other players needing a game like Mame Biram Diouf and Federico Macheda. Chris Smalling has come back and I may be able to play him on Wednesday. He’s still young and it’ll be a young squad against Palace.
“The only area where I’ve got problems is centre midfield. It’s possible I could play Pogba in there but we’ll wait and see. I’ve got enough players to choose from, that’s for sure.”
“I think the League Cup has turned into quite a good tournament,” he added. “Clubs like United are able to introduce young players and ones who have not been playing regularly in the first team and it’s been good to us over the years.”
“We’ve won two finals at Wembley with young players, which is good going, and I think it’s become an important tournament for us in terms of getting the youngsters an introduction into winning and having an understanding of the progress they’re making.”