Vilanova has been sidelined for the last four months with Jordi Roura in charge in the interim, and the club face a huge challenge to fight back from 2-0 down in the second leg of their Champions League tie with AC Milan this week.
“We really miss him,” Pique told the club’s website (www.fcbarcelona.es) on Sunday.
“It’s a difficult situation to be in, without the boss – it’s like a company without its chairman, but we will come through this,” added the Spain international.
“Tito is helping us from New York and the most important thing is his health. We’re not putting any pressure on him and we’ll be waiting for him till he gets better.
“We’ll attack from the off – which is our way of doing things – and we hope to win 3-0.”