Real Madrid face Spurs in the quarter-final first leg next month.
Ronaldo has been out of action with a hamstring injury since the derby win over Atletico Madrid last Saturday.
“I think he will be able to play against Tottenham. We don’t have a game this weekend and that will allow him to recover,” Mourinho is quoted as saying in As.
“I don’t think he can play against Sporting Gijon (in the league), if he can, I won’t risk it because I want him fit for the Champions League match.
“We hope he is back to his top level against Tottenham.”