Santacroce has been linked with a move to Real Madrid in resent weeks.
“I have a contract with Napoli and I am happy to stay here,” he told Sky Sport Italia.
“I’m clearly flattered by the interest of big clubs, but I firmly believe in this project and I want to see it out.”
“The championship is very difficult this season, as there are several strong sides,” he continued.
“We have a wonderful group and I have a special relationship with [Marek] Hamsik, who is like a brother to me.
“The Champions League? Of course, we think about it, but we need to keep our feet on the ground.
“Nonetheless, the San Paolo crowd is simply amazing and anything is possible. I dream of achieving great things with the Azzurri and possibly playing in the Champions League final sooner or later.”