The Dutchman has aggravated a calf problem in training and will not be risked against Blackpool.
“He did his calf again in training yesterday (Sunday) so he’s struggling,” Redknapp told Sky Sports News.
“He’s been having a problem with it. He missed a couple of games, came back and played in Milan. He got through 65 minutes there and then yesterday morning he felt it again. It didn’t feel good.
“It’s a blow because he’s a fantastic player. When he plays, he’s been great for us. We need him but we just can’t seem to get that run of games out of him.
“He’s missed a pre-season and I think that’s been a problem for him. He was away for the World Cup and missed getting that pre-season behind him, and he’s picked up niggling injuries since then.
“But hopefully he won’t be out too long. We’ve just got to wait and see again.”