The Russians took the lead in the 25th minute with a goal by Alan Dzagoev.
Former Real Madrid and Liverpool striker Michael Owen equalized for United, just five minutes later.
Milos Krasic sent the Russian’s back in the lead just after Owen’s goal. Aleksei Berezutski made it 1-3 just after half-time.
Federico Macheda had a great chance to get United back in the game with a header in the 80th minute, but hit the post.
Paul Scholes made it 2-3 from header in the 83th minute, following a massive pressure from United.
United continued to press forward and Antonio Valencia secured a draw for the Red Devils in the first minute of extra time, with a shot from outside the box.
Semberas was sent off for CSKA Moscow just before the final whistle.
