Jorge Molina scored a hat trick in the fourth round first-leg match at Ejido’s Santo Domingo Stadium.
Gregory Laget scored the other goals for Ejido.
Other results from the Copa Del Rey today:
Portugalete 1-4 Valencia
Orihuela 0-1 At. Madrid
Poli Ejido 5-0 Villarreal
Ponferradina 1-0 Sevilla
Elche 0-2 Deportivo
Murcia 2-1 Racing
Celta 2-2 Espanyol
Rayo Vallecano 1-2 Almería
Hércules 1-5 Valladolid
Castellón 0-2 Betis
Numancia 0-1 Sporting
Málaga 1-1 Mallorca
Athletic 2-0 Recreativo
Getafe 0-0 Osasuna