The Giallorossi lost 3-2 in the first-leg of the last 16 clash in Roma three weeks ago.
“We know how to play, and we will put Shakhtar in difficulty. The derby against Lazio? We are thinking about Shakhtar,” Totti said.
“It will be a difficult match, but we know we have to play the game and we will confront it in the best of ways.
“We will do all we can. We have hope of coming out and going through the round even though it will be tough.”