The Dutchman has along with the duo impressed at the back for United this season.
Van der Sar told The Sun: “I have not played behind a better centre-half partnership than Rio Ferdinand and Nemanja Vidic.
“The understanding between them is great. But even when Rio or Nemanja have been out, Jonny Evans has come in and done a great job also.
“There have been changes at full-back with Patrice Evra injured and suspended and Gary Neville and Wes Brown out. But it has remained well-organised and everyone knows their job.
“In fact that’s the same right through the team.
“The manager changes quite a lot of players but everyone knows what he can do in his position and what the guy left and right of them can do.”